Fig. 1. Reactions of aerobic and anaerobic glycolysis in T. brucei bloodstream forms. Boxed metabolites represent the starting and end-products of trypanosome glycolysis. Enzymes: 1, hexokinase; 2, phosphoglucose isomerase; 3, phosphofructokinase; 4, aldolase; 5, triosephosphate isomerase; 6, glyceraldehyde-3-phosphate dehydrogenase; 7, phosphoglycerate kinase; 8, glycerol-3-phosphate dehydrogenase; 9 glycerol kinase; 10, adenylate kinase; 11, glycerol-3-phosphate oxidase; 12, phosphoglycerate mutase and enolase; 13, pyruvate kinase.