Pan-Editing of mitochondrial RNA in Kinetoplasitda.

The sequence shown below represents a part of a mature mRNA that has been created by a process of pan-editing (pan-editing is editing throughout the entire length of the mRNA). Upper case letters are those also present in the DNA. Uridines which have been inserted by the editing process are indicated as lower case us in magenta and those that have been removed are indicated with an asterix (*) . Note that owing to the editing proces a start codon is being cretated so allowing for the translation of the mature mRNA.

 

Also note that the mature mRNA would not be able to hybridise with the gene present in the kinetoplast DNA and thus cannot be detected as such.

 

UCCuAuuA*AuUUUUUGuUA**UAu
   AGuuuuuuAA*UGUUGuuuGGuGuA
   *uuuuuuuAuUG*UGuuuAGuuuuG
   uuuuGuuGuuGuuuGuuuG****GU
GuGuuAuuG**UUUUGAGAuuGuuG


Last updated: 8 August 1997.

created by :Fred Opperdoes