Matrix3

Cumulative Data, Dayhoff 1978

     ala  arg  asn  asp  cys  gln  glu  gly  his  ile  leu  lys  met  phe  pro  ser  thr  trp  tyr

A
R    30
N    109  17
D    154  0    532
C    33   10   0   0
Q    93   120  50   76   0
E    266  0    94   831  0    422
G    579  10   156  162  10   30   112
H    21   103  226  43   10   243  23   10
I    66   30   36   13   17   8    35   0    3
L    95   17   37   0    0    75   15   17   40   253
K    57   477  322  85   0    147  104  60   23   43   39
M    29   17   0    0    0    20   7    7    0    57   207  90
F    20   7    7    0    0    0    0    17   20   90   167  0    17
P    345  67   27   10   10   93   40   49   50   7    43   43   4    7
S    772  137  432  98   117  47   86   450  26   20   32   168  20   40   269
T    590  20   169  57   10   37   31   50   14   129  52   200  28   10   73   696
W    0    27   3    0    0    0    0    0    3    0    13   0    0    10   0    17   0
Y    20   3    36   0    30   0    10   0    40   13   23   10   0    260  0    22   23   6
V    365  20   13   17   33   27   37   97   30   661  303  17   77   10   50   43   186  0    17

Numbers of accepted point mutations (x10) accumulated from closely related sequences. Fifteen hundred and seventy-two exchanges are shown. Fractional exchanges result when ancestral sequences are ambiguous; the probabilities are distributed equally among all possibilities. The total number of exchanges tallied was 1,572. Note that 36 exchanges, of the 190 possible, were never observed. The Asp-Glu pair had the largest number of exchanges 83.1 (Adapted from Figure 80. Atlas of Protein Sequence and Structure, Suppl 3, 1978, M.O. Dayhoff, ed. National Biomedical Research Foundation, 1979.)