ClustalW Multiple Sequence Alignment Results
Page 1.1
1 15 16 30 31 45 46 60 61 75 76 90
1 MDHM_RAT ------------MLS ALARP---VG---AA LRRS--FSTSAQNNA KVAVLGASGGIGQPL SLLLK-NSPLVSR-- --------LTLYDIA 59
2 MDHM_MOUSE ------------MLS ALARP---AG---AA LRRS--FSTSAQNNA KVAVLGASGGIGQPL SLLLK-NSPLVSR-- --------LTLYDIA 59
3 MDHM_PIG --------------- --------------- --------------A KVAVLGASGGIGQPL SLLLK-NSPLVSR-- --------LTLYDIA 35
4 MDHG_CUCSA MQPIPDVNQRIARIS AHLHPPKYQMEESSV LRRANCRAKGGAPGF KVAILGAAGGIGQPL AMLMK-MNPLVSV-- --------LHLYDVV 79
5 MDHG_SOYBN MEANSGASDRISRIA GHLRP---QREDDVC LKRSDCRAKGGVSGF KVAILGAAGGIGQPL AMLMK-MNPLVSL-- --------LHLYDVV 76
6 MDHM_CITVU MKASILRSVRSAVSR SSSSN---R-----L LSRS--FATESVPER KVAVLGAAGGIGQPL ALLMK-LNPLVSK-- --------LALYDIA 69
7 MDHM_EUCGU MRASMLRLIRSRSSS AAPRP---H-----L LRRA--YGSESVPER KVAVLGAAGGIGQPL ALLMK-LNPLVSQ-- --------LALYDIA 69
8 MDH_ECOLI --------------- --------------- --------------M KVAVLGAAGGIGQAL ALLLKTQLPSGSE-- --------LSLYDIA 36
9 MDH_SALTY --------------- --------------- --------------M KVAVLAAAGGIGQAL ALLLKNQLPSGSE-- --------LSLYDIA 36
10 MDH_PHOS9 --------------- --------------- --------------M KVAVIGAAGGIGQAL ALLLKNGLPAGSD-- --------LALYDIA 36
11 MDH_VIBS5 --------------- --------------- --------------M KVAVLGAAGGIGQAL ALLLKTQLPAGSD-- --------LSLYDIA 36
12 MDH_HAEIN --------------- --------------- --------------M KVAVLGAAGGIGQAL ALLLKLQLPAGTD-- --------LSLYDIA 36
13 MDHM_TRBRU --------------- --------------- ------MRTSATLQF KVAVLGAAGGIGQPL SLILK-TNPLVSH-- --------LSCYDIH 43
14 MDHM_YEAST --------------- ------------MLS RVAKRAFSSTVANPY KVTVLGAGGGIGQPL SLLLK-LNHKVTD-- --------LRLYDLK 52
15 PHYTO --------------- --------------- -------------MA HVCVVGAAGGVGQAL SLLLTRSLPYGST-- --------LSLYDVV 37
16 MDHG_TRBRU --------------- --------------- -------------MV SVAVIGAAGGIGQSL SLLLLRQLPYGST-- --------LSLYDVA 37
17 MDHP_YEAST --------------- --------------- --------------V KVAILGASGGVGQPL SLLLK-LSPYVSE-- --------LALYDIR 35
18 MDHC_YEAST --------------- --------------- --PHSVTPSIEQDSL KIAILGAAGGIGQSL SLLLKAQLQYQLKES NRSVTHIHLALYDVN 58
19 MDH_BACSU --------------- --------------- ---------MGNTRK KVSVIG-AGFTGATT AFLIA--QKELAD-- --------VVLVDIP 38
Page 2.1
91 105 106 120 121 135 136 150 151 165 166 180
1 MDHM_RAT --HTPGVAADLSHIE TRANVKGYLGPEQ-- ------LPDCLKGCD VVVIPAGVPRKPGMT RDDLFNTNATIVATL TAACAQHC--PEAMI 137
2 MDHM_MOUSE --HTPGVAADLSHIE TRANVKGYLGPEQ-- ------LPDCLKGCD VVVIPAGVPRKPGMT RDDLFNTNATIVATL TAACAQHC--PEAMV 137
3 MDHM_PIG --HTPGVAADLSHIE TRATVKGYLGPEQ-- ------LPDCLKGCD VVVIPAGVPRKPGMT RDDLFNTNATIVATL TAACAQHC--PDAMI 113
4 MDHG_CUCSA --NAPGVTADISHMD TGAVVRGFLGQQQ-- ------LERALTGMD LVVIPAGVPRKPGMT RDDLFKINAGIVKTL CEGIAKCC--PTAIV 157
5 MDHG_SOYBN --NTPGVTSDISHMD TGAVVRGFLGQQQ-- ------LEDALIGMD LVIIPAGVPRKPGMT RDDLFNINAGIVKTL CEAIAKCC--PKAIV 154
6 MDHM_CITVU --GTPGVAADVGHVN TRSEVTGYVGEEQ-- ------LGKALEGSD VVIIPAGVPRKPGMT RDDLFNINAGIVKSL CTAIAKYC--PNALI 147
7 MDHM_EUCGU --GTPGVAADVGHIN TRSEVAGYVGEEQ-- ------LGQALEGSD VVIIPAGVPRKPGMT RDDLFNINAGIVKSL CTAIAKYC--PNAVV 147
8 MDH_ECOLI P-VTPGVAVDLSHIP TAVKIKGFSGED--- ------ATPALEGAD VVLISAGVARKPGMD RSDLFNVNAGIVKNL VQQVAKTC--PKACI 114
9 MDH_SALTY P-VTPGVAVDLSHIP TAVKIKGFSGED--- ------ATPALEGAD VVLISAGVARKPGMD RSDLFNVNAGIVKNL VQQIAKTC--PKACV 114
10 MDH_PHOS9 P-VTPGVAADLSHIP TPVSIKGYGGVD--- ------PTPALEGAD VVLISAGVARKPGMD RSDLFNVNAGIIKSL AEKIAVVC--PKACV 114
11 MDH_VIBS5 P-VTPGVAVDLSHIP TDVTIAGFAGMD--- ------PTDALVGAD VVLISAGVARKPGMD RSDLFNINAGIIKNL AGKCAEVC--PNACI 114
12 MDH_HAEIN P-VTPGVAVDVSHIP TAVNVKGFSGED--- ------PTPALEGAD VVLISAGVARKPGMD RSDLFNINAGIVRGL IEKVAVTC--PKACV 114
13 MDHM_TRBRU --GVTGVAADLSHIC SPAKVTGHLKDE--- ------LHKAVDGAD VVIIPAGTPRKPGMT REDLFSVNATIVRDL VSACAKQC--PKALI 120
14 MDHM_YEAST --GAKGVATDLSHIP TNSVVKGFTPEEPD- -----GLNNALKDTD MVLIPAGVPRKPGMT RDDLFAINASIVRDL AAATAESA--PNAAI 132
15 PHYTO --GAPGVAADLSHID NAGVTVKFAAGKIG- VTRDPALAALATGVD VFVFVAGGPIMPGMK RDDLFNSTAGIVLDL VMTCASSS--PKAMF 122
16 MDHG_TRBRU --GAPGVAADLSHVD RAGVTVKYAAGKLPP VKRDPALAELARGVD VFVIVAGVPRKPGMS RDDLFNVNAGIIMDL VLTCGSSS--PQACF 123
17 MDHP_YEAST --AAEGIGKDLSHIN TNSSCVGYDKDS--- ------IENTLSNAQ VVLIPAGVPRKPGLT RDDLFKMNAGIVKSL VTAVGKFA--PNARI 112
18 MDHC_YEAST QEAINGVTADLSHID TPISVSSHSPAGG-- ------IENCLHNAS IVVIPAGVPRKPGMT RDDLFNVNAGIISQL GDSIAECCDLSKVFV 140
19 MDH_BACSU QLENPTKGKALDMLE A-SPVQGFDAKITG- ----TSNYEDTAGSD IVVITAGIARKPGMS RDDLVSTNEKIMRSV TQEIVKYS--PDSII 120
Page 3.1
181 195 196 210 211 225 226 240 241 255 256 270
1 MDHM_RAT CIISNPVNSTIPITA -EVFKKHG-VYN--- PNKIFGVT-TLDIVR ANTFVAELKGLD--- --------PARVNVP VIGGHAGKTIIPLIS 210
2 MDHM_MOUSE CIIANPVNSTIPITA -EVFKKHG-VYN--- PNKIFGVT-TLDIVR ANTFVAELKGLD--- --------PARVNVP VIGGHAGKTIIPLIS 210
3 MDHM_PIG CIISNPVNSTIPITA -EVFKKHG-VYN--- PNKIFGVT-TLDIVR ANAFVAELKGLD--- --------PARVSVP VIGGHAGKTIIPLIS 186
4 MDHG_CUCSA NLISNPVNSTVPIAA -EVFKKAG-TYD--- PKRLLGVT-MLDVVR ANTFVAEVLGLD--- --------PRDVNVP VVGGHAGVTILPLLS 230
5 MDHG_SOYBN NVISNPVNSTVPIAA -EVFKRAG-TYD--- PKRLLGVT-MLDVVR ANTFVAEVLGVD--- --------PRDVDVP VVGGHAGITILPLLS 227
6 MDHM_CITVU NMISNPVNSTVPIAA -EVFKKAG-TYD--- EKKLFGVT-TLDVVR AKTFYAGKANVP--- --------VAEVNVP VIGGHAGITILPLFS 220
7 MDHM_EUCGU NMISNPVNSTVPIAA -EIFKKAG-TYN--- EKKLLGVT-TLDVVR AKTFYAGKAKVP--- --------VEEVNVP VVGGHAGITILPLFS 220
8 MDH_ECOLI GIITNPVNTTVAIAA -EVLKKAG-VYD--- KNKLFGVT-TLDIIR SNTFVAELKGKQ--- --------PGEVEVP VIGGHSGVTILPLLS 187
9 MDH_SALTY GIITNPVNTTVAIAA -EVLKKAG-VYD--- KNKLFGVT-TLDIIR SNPFVAELKGKL--- --------PTEVEVP VIGGHSGVTILPLLS 187
10 MDH_PHOS9 GIITNPVNTTVAIAA -DVLKKAG-VYD--- KRRLFGIT-TLDIIR SETFVAELKGKT--- --------PSELQVP VIGGHSGVTILPLLS 187
11 MDH_VIBS5 GIITNPVNTTVPIAA -EVLKQAG-VYD--- KRKLFGIT-TLDVIR SETFVSALKGIS--- --------LADVEVP VIGGHSGVTILPLLS 187
12 MDH_HAEIN GIITNPVNTTVAIAA -EVLKKAG-VYD--- KRKLFGVT-TLDVLR SETFVAELKGLN--- --------VSRTSVP VIGGHSGVTILPLLS 187
13 MDHM_TRBRU GVVSNPVNSVVPIAS -EVLKKAG-VFD--- PARLFGIT-TLDVVR ARTFVAEAAGKS--- --------PYDVNVQ VVGGHSGPTIIPLLS 193
14 MDHM_YEAST LVISNPVNSTVPIVA -QVLKNKG-VYN--- PKKLFGVT-TLDSIR AARFISEVENTD--- --------PTQERVN VIGGHSGITIIPLIS 205
15 PHYTO CMISNPVNSTVPIAA -EVLKKLG-VYN--- KNRLLGVT-RLDMLR ATRFINEAR-MP--- --------LVVDRVP VVGGHSDNSIVPLFH 194
16 MDHG_TRBRU CVVTNPVNSTVPIAA -EALKKLG-IYN--- KNKLLGVT-LLDGLR ATRFINNAR-HP--- --------LAVASVP VVGGHSDVTIVPLFS 195
17 MDHP_YEAST LVISNPVNSLVPIAV -ETLKKMG-KFK--- PGNVMGVT-NLDLVR AETFLVDYLMLKNPK IGQEQDKTTMHRKVT VIGGHSGETIIPIIT 196
18 MDHC_YEAST LVISNPVNSLVPVMV SNILKNHPQSRNSGI ERRIMGVT-KLDIVR ASTFLREINIESG-- ---LTPRVNSMPDVP VIGGHSGETIIPLFS 224
19 MDH_BACSU VVLTNPVDAMTYAVY ----KESG--FP--- KERVIGQSGVLDTAR FRTFVAEELNLS--- --------VKDVTGF VLGGH-GDDMVPLVR 189
Page 4.1
271 285 286 300 301 315 316 330 331 345 346 360
1 MDHM_RAT QCTP-----KVDFPQ DQLATLTGKIQEAGT EVVKAKAGAGSATLS MAYAGARFVFSLVDA MNGKEG----VIECS FVQS----------- 280
2 MDHM_MOUSE QCTP-----KVDFPQ DQLATLTGRIQEAGT EVVKAKAGAGSATLS MAYAGARFVFSLVDA MNGLEG----VVECS FVQS----------- 280
3 MDHM_PIG QCTP-----KVDFPQ DQLSTLTGRIQEAGT EVVKAKAGAGSATLS MAYAGARFVFSLVDA MNGKEG----VVECS FVKS----------- 256
4 MDHG_CUCSA QVKP-----PSSFTQ EEINYLTDRIQNGGT EVVEAKAGAGSATLS MAYAAVKFADACLRG LRGDAG----VVECA FVSS----------- 300
5 MDHG_SOYBN QIKP-----PCSFTP KEIEYLTGRIQNGGP EVVEAKAGAGSATLS MAYAAVKFADACLHA LRGDAG----IIECA YVAS----------- 297
6 MDHM_CITVU QATP-----RANLSD DTIVALTKRTQDGGT EVVEAKAGKGSATLS MAYAGALFADACLKG LNGVPD----VVECS FVQS----------- 290
7 MDHM_EUCGU QAVP-----KANLAD EDIKALTKRTQDGGT EVVEAKAGKGSATLS MAYAGALFADACLKG LNGVPD----VVECS FVQSS---------- 291
8 MDH_ECOLI QVPG------VSFTE QEVADLTKRIQNAGT EVVEAKAGGGSATLS MGQAAARFGLSLVRA LQGEQG----VVECA YVEG----------- 256
9 MDH_SALTY QIPG------VSFTE QEAAELTKRIQNAGT EVVEAKAGGGSATLS MGQAAARFGVSLVRA LQGEKG----VVECA YVEG----------- 256
10 MDH_PHOS9 QVEG------VEFSD EEIKALTPRIQNAGT EVVEAKRGGGSATLS MGQAAYRFGLSLVRA LQGQQG----IVECA YVEG----------- 256
11 MDH_VIBS5 QVKG------VEFTA EEVVALTARIQNAGT EVVEAKAGGGSATLS MGQAAARFGLSLVRA LQGEKG----IVECT YVDG----------- 256
12 MDH_HAEIN QVQY------AKWNE DEIEPLTKRIQNAGT EVLNAKAGGGSATLS MAQAAARFARSLVKG LSGET-----VVECT YVEG----------- 255
13 MDHM_TRBRU QAG-------VSLTE EQVKAITHRVQYGGD EVVKAKGGAGSATLS MAYAAGEWMSSVLKG LRGDKG----IVECT YVQTD---------- 262
14 MDHM_YEAST QTN------HKLMSD DKRHELIHRIQFGGD EVVKAKNGAGSATLS MAHAGAKFANAVLSG FKGERD----VIEPS FVDSPL--------- 276
15 PHYTO QLQG------PLPPK EQLDKITLRVQSAAY EVIDAKGGRGSATLA MGEAGARFVLDVVKG LTGASN----PLVYA YVDTD---------- 264
16 MDHG_TRBRU QLPG------PLPEE GELTQIRKRVQVAGT EVVKAKAGRGSATLS MAEAGARFAMFVVNA ITGQSS----PMVYA YVDTD---------- 265
17 MDHP_YEAST DKS------LVFQLD KQYEHFIHRVQFGGD EIVKAKQGAGSATLS MAFAGAKFAEEVLRS FHNEKPETESLSAFV YLPGLKNGKKAQQL- 279
18 MDHC_YEAST QSNF-----LSRLNE DQLKYLIHRVQYGGD EVVKAKNGKGSATLS MAHAGYKCVVQFVSL LLGNIEQ---IHGTY YVPLKDANNFPIAPG 306
19 MDH_BACSU YSYAGGIPLETLIPK ERIDAIVERTRKGGG EIVNL-LGNGSAYYA PAASLTEMVEAILKD QRRVLP------TIA YLEG----------- 261
Page 5.1
361 375 376 390 391 405 406 420 421 435 436 450
1 MDHM_RAT ------KETECTYFS TPLLLGKKGLEKNLG --IGKITPFEE-KMI AEAIPELKASIKKGE DFVK--NMK- 338
2 MDHM_MOUSE ------KETECTYFS TPLLLGKKGLEKNLG --IGKITPFEE-KMI AEAIPELKASIKKGE DFVK--NMK- 338
3 MDHM_PIG ------QETDCPYFS TPLLLGKKGIEKNLG --IGKISPFEE-KMI AEAIPELKASIKKGE EFVK--NMK- 314
4 MDHG_CUCSA ------QVTELPFFA TKVRLGRNGIDEVYS --LGPLNEYER-IGL EKAKKELAGSIEKGV SFIR--G--- 356
5 MDHG_SOYBN ------QVTELPFFA SKVRLGRVGVEEILP --LGPLNDYER-ESL EKAKKELAASIEKGI SFIR--K--- 353
6 MDHM_CITVU ------TVTELPFFA SKVKLGKNGVESVLD --LGPLSDFEK-EGL EKLKPELKASIEKGI QFAN--AN-- 347
7 MDHM_EUCGU ------IITELPFFA SKVKLGKNGVEEVLE --LGPMSDYEK-QGL EILIPELKASIEKGI KFAN--Q--- 347
8 MDH_ECOLI ------DGQYARFFS QPLLLGKNGVEERKS --IGTLSAFEQ-NAL EGMLDTLKKDIALGE EFVN--K--- 312
9 MDH_SALTY ------DGQYARFFS QPLLLGKNGVEERKS --IGTLSAFEQ-HSL DAMLDTLKKDIQLGE EIIN--K--- 312
10 MDH_PHOS9 ------DGKHARFFA QPVLLGKDGVEEVID --YGKLSTFEQ-EAL NNMLDTLTSDITLGE EFAA--K--- 312
11 MDH_VIBS5 ------GSEHATFFA QPVLLGKNGVEEVLA --YGELSEFET-NAR DAMLEELKANITLGE EFVA--G--- 312
12 MDH_HAEIN ------DGKYARFFS QPVRLGKEGVEEILP --IGPLSNFEQ-QAL ENMLPTLRADIELGE KFIN--G--- 311
13 MDHM_TRBRU ------IIPGVNFFG CPVELGKGGVEKIHK --P-VFDAYEQ-SLL EKCVADLEKNIAAGF AFGS--RQ-- 318
14 MDHM_YEAST -----FKSEGIEFFA SPVTLGPDGIEKIHP --IGELSSEEE-EML QKCKETLKKNIEKGV NFVA--SK-- 334
15 PHYTO ------GQSESEFLA IPVILGKSGIERRLP --IGPMTESEK-KLV DVAISIVKKNIEKGK EFAL--SKL- 322
16 MDHG_TRBRU ------GTQNCSFLA IPVVLGKNGIEKRLP --IGPMNAVEK-EML KQSISVVKANIEKGM NFAR--SKL- 323
17 MDHP_YEAST -----VGDNSIEYFS LPIVLRNGSVVSIDT SVLEKLSPREE-QLV NTAVKELRKNIEKGK SFILDSSKL- 342
18 MDHC_YEAST ADQLLPLVDGADYFA IPLTITTKGVSYVDY DIVNRMNDMERNQML PICVSQLKKNIDKGL EFVASRSASS 376
19 MDH_BACSU -----EYGYEGIYLG VPTIVGGNGLEQIIE ---LELTDYER-AQL NKSVESVKNVMKVLS ---------- 312
Alignment Data (Fasta format)
>MDHM_RAT
------------MLSALARP---VG---AALRRS--FSTSAQNNAKVAVL
GASGGIGQPLSLLLK-NSPLVSR----------LTLYDIA--HTPGVAAD
LSHIETRANVKGYLGPEQ--------LPDCLKGCDVVVIPAGVPRKPGMT
RDDLFNTNATIVATLTAACAQHC--PEAMICIISNPVNSTIPITA-EVFK
KHG-VYN---PNKIFGVT-TLDIVRANTFVAELKGLD-----------PA
RVNVPVIGGHAGKTIIPLISQCTP-----KVDFPQDQLATLTGKIQEAGT
EVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEG----VIECSFVQS-
----------------KETECTYFSTPLLLGKKGLEKNLG--IGKITPFE
E-KMIAEAIPELKASIKKGEDFVK--NMK-
>MDHM_MOUSE
------------MLSALARP---AG---AALRRS--FSTSAQNNAKVAVL
GASGGIGQPLSLLLK-NSPLVSR----------LTLYDIA--HTPGVAAD
LSHIETRANVKGYLGPEQ--------LPDCLKGCDVVVIPAGVPRKPGMT
RDDLFNTNATIVATLTAACAQHC--PEAMVCIIANPVNSTIPITA-EVFK
KHG-VYN---PNKIFGVT-TLDIVRANTFVAELKGLD-----------PA
RVNVPVIGGHAGKTIIPLISQCTP-----KVDFPQDQLATLTGRIQEAGT
EVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGLEG----VVECSFVQS-
----------------KETECTYFSTPLLLGKKGLEKNLG--IGKITPFE
E-KMIAEAIPELKASIKKGEDFVK--NMK-
>MDHM_PIG
--------------------------------------------AKVAVL
GASGGIGQPLSLLLK-NSPLVSR----------LTLYDIA--HTPGVAAD
LSHIETRATVKGYLGPEQ--------LPDCLKGCDVVVIPAGVPRKPGMT
RDDLFNTNATIVATLTAACAQHC--PDAMICIISNPVNSTIPITA-EVFK
KHG-VYN---PNKIFGVT-TLDIVRANAFVAELKGLD-----------PA
RVSVPVIGGHAGKTIIPLISQCTP-----KVDFPQDQLSTLTGRIQEAGT
EVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEG----VVECSFVKS-
----------------QETDCPYFSTPLLLGKKGIEKNLG--IGKISPFE
E-KMIAEAIPELKASIKKGEEFVK--NMK-
>MDHG_CUCSA
MQPIPDVNQRIARISAHLHPPKYQMEESSVLRRANCRAKGGAPGFKVAIL
GAAGGIGQPLAMLMK-MNPLVSV----------LHLYDVV--NAPGVTAD
ISHMDTGAVVRGFLGQQQ--------LERALTGMDLVVIPAGVPRKPGMT
RDDLFKINAGIVKTLCEGIAKCC--PTAIVNLISNPVNSTVPIAA-EVFK
KAG-TYD---PKRLLGVT-MLDVVRANTFVAEVLGLD-----------PR
DVNVPVVGGHAGVTILPLLSQVKP-----PSSFTQEEINYLTDRIQNGGT
EVVEAKAGAGSATLSMAYAAVKFADACLRGLRGDAG----VVECAFVSS-
----------------QVTELPFFATKVRLGRNGIDEVYS--LGPLNEYE
R-IGLEKAKKELAGSIEKGVSFIR--G---
>MDHG_SOYBN
MEANSGASDRISRIAGHLRP---QREDDVCLKRSDCRAKGGVSGFKVAIL
GAAGGIGQPLAMLMK-MNPLVSL----------LHLYDVV--NTPGVTSD
ISHMDTGAVVRGFLGQQQ--------LEDALIGMDLVIIPAGVPRKPGMT
RDDLFNINAGIVKTLCEAIAKCC--PKAIVNVISNPVNSTVPIAA-EVFK
RAG-TYD---PKRLLGVT-MLDVVRANTFVAEVLGVD-----------PR
DVDVPVVGGHAGITILPLLSQIKP-----PCSFTPKEIEYLTGRIQNGGP
EVVEAKAGAGSATLSMAYAAVKFADACLHALRGDAG----IIECAYVAS-
----------------QVTELPFFASKVRLGRVGVEEILP--LGPLNDYE
R-ESLEKAKKELAASIEKGISFIR--K---
>MDHM_CITVU
MKASILRSVRSAVSRSSSSN---R-----LLSRS--FATESVPERKVAVL
GAAGGIGQPLALLMK-LNPLVSK----------LALYDIA--GTPGVAAD
VGHVNTRSEVTGYVGEEQ--------LGKALEGSDVVIIPAGVPRKPGMT
RDDLFNINAGIVKSLCTAIAKYC--PNALINMISNPVNSTVPIAA-EVFK
KAG-TYD---EKKLFGVT-TLDVVRAKTFYAGKANVP-----------VA
EVNVPVIGGHAGITILPLFSQATP-----RANLSDDTIVALTKRTQDGGT
EVVEAKAGKGSATLSMAYAGALFADACLKGLNGVPD----VVECSFVQS-
----------------TVTELPFFASKVKLGKNGVESVLD--LGPLSDFE
K-EGLEKLKPELKASIEKGIQFAN--AN--
>MDHM_EUCGU
MRASMLRLIRSRSSSAAPRP---H-----LLRRA--YGSESVPERKVAVL
GAAGGIGQPLALLMK-LNPLVSQ----------LALYDIA--GTPGVAAD
VGHINTRSEVAGYVGEEQ--------LGQALEGSDVVIIPAGVPRKPGMT
RDDLFNINAGIVKSLCTAIAKYC--PNAVVNMISNPVNSTVPIAA-EIFK
KAG-TYN---EKKLLGVT-TLDVVRAKTFYAGKAKVP-----------VE
EVNVPVVGGHAGITILPLFSQAVP-----KANLADEDIKALTKRTQDGGT
EVVEAKAGKGSATLSMAYAGALFADACLKGLNGVPD----VVECSFVQSS
----------------IITELPFFASKVKLGKNGVEEVLE--LGPMSDYE
K-QGLEILIPELKASIEKGIKFAN--Q---
>MDH_ECOLI
--------------------------------------------MKVAVL
GAAGGIGQALALLLKTQLPSGSE----------LSLYDIAP-VTPGVAVD
LSHIPTAVKIKGFSGED---------ATPALEGADVVLISAGVARKPGMD
RSDLFNVNAGIVKNLVQQVAKTC--PKACIGIITNPVNTTVAIAA-EVLK
KAG-VYD---KNKLFGVT-TLDIIRSNTFVAELKGKQ-----------PG
EVEVPVIGGHSGVTILPLLSQVPG------VSFTEQEVADLTKRIQNAGT
EVVEAKAGGGSATLSMGQAAARFGLSLVRALQGEQG----VVECAYVEG-
----------------DGQYARFFSQPLLLGKNGVEERKS--IGTLSAFE
Q-NALEGMLDTLKKDIALGEEFVN--K---
>MDH_SALTY
--------------------------------------------MKVAVL
AAAGGIGQALALLLKNQLPSGSE----------LSLYDIAP-VTPGVAVD
LSHIPTAVKIKGFSGED---------ATPALEGADVVLISAGVARKPGMD
RSDLFNVNAGIVKNLVQQIAKTC--PKACVGIITNPVNTTVAIAA-EVLK
KAG-VYD---KNKLFGVT-TLDIIRSNPFVAELKGKL-----------PT
EVEVPVIGGHSGVTILPLLSQIPG------VSFTEQEAAELTKRIQNAGT
EVVEAKAGGGSATLSMGQAAARFGVSLVRALQGEKG----VVECAYVEG-
----------------DGQYARFFSQPLLLGKNGVEERKS--IGTLSAFE
Q-HSLDAMLDTLKKDIQLGEEIIN--K---
>MDH_PHOS9
--------------------------------------------MKVAVI
GAAGGIGQALALLLKNGLPAGSD----------LALYDIAP-VTPGVAAD
LSHIPTPVSIKGYGGVD---------PTPALEGADVVLISAGVARKPGMD
RSDLFNVNAGIIKSLAEKIAVVC--PKACVGIITNPVNTTVAIAA-DVLK
KAG-VYD---KRRLFGIT-TLDIIRSETFVAELKGKT-----------PS
ELQVPVIGGHSGVTILPLLSQVEG------VEFSDEEIKALTPRIQNAGT
EVVEAKRGGGSATLSMGQAAYRFGLSLVRALQGQQG----IVECAYVEG-
----------------DGKHARFFAQPVLLGKDGVEEVID--YGKLSTFE
Q-EALNNMLDTLTSDITLGEEFAA--K---
>MDH_VIBS5
--------------------------------------------MKVAVL
GAAGGIGQALALLLKTQLPAGSD----------LSLYDIAP-VTPGVAVD
LSHIPTDVTIAGFAGMD---------PTDALVGADVVLISAGVARKPGMD
RSDLFNINAGIIKNLAGKCAEVC--PNACIGIITNPVNTTVPIAA-EVLK
QAG-VYD---KRKLFGIT-TLDVIRSETFVSALKGIS-----------LA
DVEVPVIGGHSGVTILPLLSQVKG------VEFTAEEVVALTARIQNAGT
EVVEAKAGGGSATLSMGQAAARFGLSLVRALQGEKG----IVECTYVDG-
----------------GSEHATFFAQPVLLGKNGVEEVLA--YGELSEFE
T-NARDAMLEELKANITLGEEFVA--G---
>MDH_HAEIN
--------------------------------------------MKVAVL
GAAGGIGQALALLLKLQLPAGTD----------LSLYDIAP-VTPGVAVD
VSHIPTAVNVKGFSGED---------PTPALEGADVVLISAGVARKPGMD
RSDLFNINAGIVRGLIEKVAVTC--PKACVGIITNPVNTTVAIAA-EVLK
KAG-VYD---KRKLFGVT-TLDVLRSETFVAELKGLN-----------VS
RTSVPVIGGHSGVTILPLLSQVQY------AKWNEDEIEPLTKRIQNAGT
EVLNAKAGGGSATLSMAQAAARFARSLVKGLSGET-----VVECTYVEG-
----------------DGKYARFFSQPVRLGKEGVEEILP--IGPLSNFE
Q-QALENMLPTLRADIELGEKFIN--G---
>MDHM_TRBRU
------------------------------------MRTSATLQFKVAVL
GAAGGIGQPLSLILK-TNPLVSH----------LSCYDIH--GVTGVAAD
LSHICSPAKVTGHLKDE---------LHKAVDGADVVIIPAGTPRKPGMT
REDLFSVNATIVRDLVSACAKQC--PKALIGVVSNPVNSVVPIAS-EVLK
KAG-VFD---PARLFGIT-TLDVVRARTFVAEAAGKS-----------PY
DVNVQVVGGHSGPTIIPLLSQAG-------VSLTEEQVKAITHRVQYGGD
EVVKAKGGAGSATLSMAYAAGEWMSSVLKGLRGDKG----IVECTYVQTD
----------------IIPGVNFFGCPVELGKGGVEKIHK--P-VFDAYE
Q-SLLEKCVADLEKNIAAGFAFGS--RQ--
>MDHM_YEAST
---------------------------MLSRVAKRAFSSTVANPYKVTVL
GAGGGIGQPLSLLLK-LNHKVTD----------LRLYDLK--GAKGVATD
LSHIPTNSVVKGFTPEEPD------GLNNALKDTDMVLIPAGVPRKPGMT
RDDLFAINASIVRDLAAATAESA--PNAAILVISNPVNSTVPIVA-QVLK
NKG-VYN---PKKLFGVT-TLDSIRAARFISEVENTD-----------PT
QERVNVIGGHSGITIIPLISQTN------HKLMSDDKRHELIHRIQFGGD
EVVKAKNGAGSATLSMAHAGAKFANAVLSGFKGERD----VIEPSFVDSP
L--------------FKSEGIEFFASPVTLGPDGIEKIHP--IGELSSEE
E-EMLQKCKETLKKNIEKGVNFVA--SK--
>PHYTO
-------------------------------------------MAHVCVV
GAAGGVGQALSLLLTRSLPYGST----------LSLYDVV--GAPGVAAD
LSHIDNAGVTVKFAAGKIG-VTRDPALAALATGVDVFVFVAGGPIMPGMK
RDDLFNSTAGIVLDLVMTCASSS--PKAMFCMISNPVNSTVPIAA-EVLK
KLG-VYN---KNRLLGVT-RLDMLRATRFINEAR-MP-----------LV
VDRVPVVGGHSDNSIVPLFHQLQG------PLPPKEQLDKITLRVQSAAY
EVIDAKGGRGSATLAMGEAGARFVLDVVKGLTGASN----PLVYAYVDTD
----------------GQSESEFLAIPVILGKSGIERRLP--IGPMTESE
K-KLVDVAISIVKKNIEKGKEFAL--SKL-
>MDHG_TRBRU
-------------------------------------------MVSVAVI
GAAGGIGQSLSLLLLRQLPYGST----------LSLYDVA--GAPGVAAD
LSHVDRAGVTVKYAAGKLPPVKRDPALAELARGVDVFVIVAGVPRKPGMS
RDDLFNVNAGIIMDLVLTCGSSS--PQACFCVVTNPVNSTVPIAA-EALK
KLG-IYN---KNKLLGVT-LLDGLRATRFINNAR-HP-----------LA
VASVPVVGGHSDVTIVPLFSQLPG------PLPEEGELTQIRKRVQVAGT
EVVKAKAGRGSATLSMAEAGARFAMFVVNAITGQSS----PMVYAYVDTD
----------------GTQNCSFLAIPVVLGKNGIEKRLP--IGPMNAVE
K-EMLKQSISVVKANIEKGMNFAR--SKL-
>MDHP_YEAST
--------------------------------------------VKVAIL
GASGGVGQPLSLLLK-LSPYVSE----------LALYDIR--AAEGIGKD
LSHINTNSSCVGYDKDS---------IENTLSNAQVVLIPAGVPRKPGLT
RDDLFKMNAGIVKSLVTAVGKFA--PNARILVISNPVNSLVPIAV-ETLK
KMG-KFK---PGNVMGVT-NLDLVRAETFLVDYLMLKNPKIGQEQDKTTM
HRKVTVIGGHSGETIIPIITDKS------LVFQLDKQYEHFIHRVQFGGD
EIVKAKQGAGSATLSMAFAGAKFAEEVLRSFHNEKPETESLSAFVYLPGL
KNGKKAQQL------VGDNSIEYFSLPIVLRNGSVVSIDTSVLEKLSPRE
E-QLVNTAVKELRKNIEKGKSFILDSSKL-
>MDHC_YEAST
--------------------------------PHSVTPSIEQDSLKIAIL
GAAGGIGQSLSLLLKAQLQYQLKESNRSVTHIHLALYDVNQEAINGVTAD
LSHIDTPISVSSHSPAGG--------IENCLHNASIVVIPAGVPRKPGMT
RDDLFNVNAGIISQLGDSIAECCDLSKVFVLVISNPVNSLVPVMVSNILK
NHPQSRNSGIERRIMGVT-KLDIVRASTFLREINIESG-----LTPRVNS
MPDVPVIGGHSGETIIPLFSQSNF-----LSRLNEDQLKYLIHRVQYGGD
EVVKAKNGKGSATLSMAHAGYKCVVQFVSLLLGNIEQ---IHGTYYVPLK
DANNFPIAPGADQLLPLVDGADYFAIPLTITTKGVSYVDYDIVNRMNDME
RNQMLPICVSQLKKNIDKGLEFVASRSASS
>MDH_BACSU
---------------------------------------MGNTRKKVSVI
G-AGFTGATTAFLIA--QKELAD----------VVLVDIPQLENPTKGKA
LDMLEA-SPVQGFDAKITG-----TSNYEDTAGSDIVVITAGIARKPGMS
RDDLVSTNEKIMRSVTQEIVKYS--PDSIIVVLTNPVDAMTYAVY----K
ESG--FP---KERVIGQSGVLDTARFRTFVAEELNLS-----------VK
DVTGFVLGGH-GDDMVPLVRYSYAGGIPLETLIPKERIDAIVERTRKGGG
EIVNL-LGNGSAYYAPAASLTEMVEAILKDQRRVLP------TIAYLEG-
---------------EYGYEGIYLGVPTIVGGNGLEQIIE---LELTDYE
R-AQLNKSVESVKNVMKVLS----------
Kim C. Worley, Human Genome Center, Baylor College of Medicine
kworley@bcm.tmc.edu