Intracellular survival of Leishmania

Leishmania survives lysosomal killing and even divides inside the phagolysosomal compartment of macrophages.

This lysosomal compartment is a very hostile environment where cells that have been interiorized by the macrophage are normally killed by a series of the following mechanisms:

Leishmania on the contrary survives in this hostile environment, but at present it is not exactly known how it is able to defend itself to the attack by the macrophage:

`The following observations have bee made

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Last updated: 9 November 1997.

created by :Fred Opperdoes