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European Commission |
Proteins of the redox metabolism as targets for the development of new drugs against malaria and other protozoan infections
Meeting organizers: Rolf D. Walter, Luise Krauth-Siegel, Eva Liebau, Sylke Müller
Programme
Thursday 29 August:
14.00 -14.30 Opening of the Meeting by Bernhard Fleischer (Director of the BNI) and Fred Opperdoes (Chairman of the COST B9 Action)
Afternoon - Session 1: Redox metabolism and validation of potential drug targets
14.30 - 15.15
C.H. Williams (Ann Arbor, USA): Catalytic mechanism of the
high molecular weight thioredoxin
reductase
15.15 - 15.45
Heiner Schirmer (Heidelberg, Germany): Glutathione reductase:
structure and inhibition
15.45 - 16.15 Coffee
16.15 - 16.45
Katja Becker-Brandenburg (Gießen, Germany): Thioredoxin
and glutaredoxin in Plasmodium
falciparum
16.45 - 17.15
Sylke Müller (Dundee, UK): Validation of thioredoxin
reductase as a drug target in Plasmodium falciparum
Friday 30 August:
Session 1: Redox metabolism and validation of potential drug targets (continued)
09.00 - 09.30
Sandra Oza (Dundee, UK): The synthesis of trypanothione as a
potential drug target
09.30 - 10.00
Leopold Flohe (Braunschweig, Germany): Tryparedoxin and
tryparedoxin peroxidase
10.00 -10.30
Daniel Dive (Lille, France): Superoxide dismutase in
Plasmodium
10.30 -11.00
Fred Opperdoes (Brussels, Belgium): Identification of a
potential glycosomal ascorbate peroxidase gene in Trypanosoma
brucei
11.00 - 11.30 Coffee
Session 2: Detoxification and drug
resistance
11.30 - 12.15
Paul J. Thornalley (Colchester, UK): The glyoxalase system.
Glyoxalase I inhibitors as antitumor (and
antimalarial) agents
12.15 - 12.45
Luise Krauth-Siegel (Heidelberg, Germany): The glyoxalase
system in trypanosomatids
12.45 - 13.15
Eva Liebau (Hamburg, Germany): Glutathione dependent
detoxification processes in Plasmodium
13.15 - 14.30 Lunch
14.30 - 15.00
Marc Ouellette (Quebec, Canada) Drug resistance related to
thiol metabolism
15.00 - 15.30
Iris Bruchhaus (Hamburg, Germany) Metronidazole resistance in
Entamoeba (including aspects of the
redox metabolism in anaerobic protozoa)
15.30 - 16.00
Graham Coombs (Glasgow, UK) The thioredoxin system of
Trichomonas vaginalis
16.00 - 16.30 Coffee
Session 3: Target structures, drug design and screening
16.30 - 17.00
Koen Augustyns (Antwerps, Belgium): Trypanothione as
target in the design of antitrypanosoma and
antileishmanial agents
17.00 - 17.30
Ken T. Douglas (Manchester, UK): Design of trypanothione
reductase inhibitors
Saturday 31 August
Morning - Session 3 (continued)
09.30 - 10.00
Elisabeth Davioud-Charvet (Lille, France - presently in
USA): Naphthoquinones as inhibitors
of trypanothione reductase
10.00 - 10.30
Christof Werner (Marburg, Germany): Structure of the P.
falciparum glutamate dehydrogenase
10.30 - 11.00
Narimantas Cenas (Vilnius, Littauen) Antiplasmodial activity
of nitroaromatic and quinoidal compounds
11.00 - 11.30 Coffee
11.30 - 12.00
C.W. Jefford (Geneva, Switzerland): Artemisinin and
derivatives
12.00 - 13.00 Summary, agreeing priorities for future studies
Afternoon - Departure
