Fred Opperdoes' full papers
and reviews since 1991
Only full papers are listed for the following years:
1991, 1992, 1993,
1994, 1995, 1996,
1997, 1998, 1999,
2000, 2001, 2002,
2003
1991
- Allert, S., Ernest, I., Poliszczak, A., Opperdoes, F.R. &
Michels, P.A.M. (1991) Molecular cloning and analysis of two
tandemly-linked genes for pyruvate kinase of Trypanosoma brucei.
Eur.
J. Biochem., 200, 19-27.
- Callens, M. & Opperdoes, F.R. (1991) Chemical modification
of fructose-bisphosphate aldolase from Trypanosoma brucei:
comparison with the enzymes from rabbit muscle and Staphylococcus
aureus. Mol.
Biochem. Parasitol., 47, 11-18.
- Callens, M., Kuntz, D.A. & Opperdoes, F.R. (1991) Kinetic
properties of fructose-bisphosphate aldolase from Trypanosoma
brucei: comparison with the enzymes from rabbit muscle and
Staphylococcus aureus. Mol.
Biochem. Parasitol., 47, 1-10.
- Callens, M., Kuntz, D.A. & Opperdoes, F.R. (1991)
Characterization of pyruvate kinase of Trypanosoma brucei and its
role in the regulation of carbohydrate metabolism. Mol.
Biochem. Parasitol., 47, 19-30.
- Coppens, I., Bastin, Ph., Courtoy, P.J., Baudhuin, P. &
Opperdoes, F.R. (1991) A rapid method purifies a glycoprotein of
Mr 145,000 as the LDL-receptor of Trypanosoma brucei brucei.
Biochem.
Biophys. Res. Comm., 178, 185-191.
- Lambeir, A.-M., Loiseau, A., Kuntz, D.A., Vellieux, F.M.D.,
Michels, P.A.M. & Opperdoes, F.R. (1991) The cytosolic and
glycosomal glyceraldehyde 3-phosphate dehydrogenase isoenzymes
from Trypanosoma brucei: Kinetic properties and comparison with
homologous enzymes. Eur.
J. Biochem., 198, 429-435.
- Michels, P.A.M., Marchand, M., Kohl, L., Allert, S., Wierenga,
R.K. & Opperdoes, F.R. (1991) The cytosolic and glycosomal
isoenzymes of glyceraldehyde-3-phosphate dehydrogenase in
Trypanosoma brucei have a distant evolutionary relationship.
Eur.
J. Biochem., 198, 421-428.
- Michels, P.A.M. & Opperdoes, F.R. (1991) The evolutionary
origin of glycosomes. Parasitol. Today, 7, 105-109.
- Noble, M.E.M., Wierenga, R.K., Lambeir, A.-M., Opperdoes,
F.R., Thunnissen, A.-M, Kalk, K.H., Groendijk, H. & Hol,
W.G.J. (1991) The adaptability of the active site of trypanosomal
triosephosphate isomerase as observed in the crystal structures of
three different complexes. Proteins,
10, 50-69.
- Opperdoes, F.R. (1991) The glycosome of the Kinetoplastida.
In: "Biochemical Protozoology", (Coombs, G.H. and North, M.J.,
eds), Taylor and Francis, London, Washington DC, pp. 134-144.
- Opperdoes, F.R. (1991) Rational drug design for parasitic
diseases. Bull. Séanc. Acad. Roy. Sci. Outre-Mer, 36,
219-233
- Smith, K., Opperdoes, F.R. & Fairlamb, A.H. (1991)
Subcellular distribution of trypanothione reductase in bloodstream
and procyclic forms of Trypanosoma brucei brucei. Mol.
Biochem. Parasitol., 48, 109-112.
- Ter Kuile, B.H. & Opperdoes, F.R. (1991) Glucose uptake by
Trypanosoma brucei: rate-limiting steps in glycolysis and
regulation of the glycolytic flux. J.
Biol. Chem., 266, 857-862.
- Ter Kuile, B.H. & Opperdoes, F.R. (1991) Chemostat
cultures of Leishmania donovani promastigotes and Trypanosoma
brucei procyclic trypomastigotes. Mol.
Biochem. Parasitol., 45, 171-174.
Top
1992
- Wierenga, R.K., Noble, M.E.M., Postma, J.P.M., Hol, W.G.J.
& Opperdoes, F.R. (1991) The crystal structure of the "open"
and the "closed" conformation of the flexible loop of trypanosomal
triosephosphate isomerase. Proteins,
10, 33-49.
- Callens, M. & Opperdoes, F.R. (1992) Some kinetic
properties of pyruvate kinase from T.brucei. Mol.
Bichem. Parasitol., 50, 235-244.
- Coppens, I., Bastin, Ph., Opperdoes, F.R., Baudhuin, P. &
Courtoy, P.J. (1992) Trypanosoma brucei brucei: antigenic
stability of its LDL receptor and immunological cross-reactivity
with the LDL receptor of the mammalian host. Exp.
Parasitol., 74, 77-86.
- Coppens, I., Bastin, Ph., Baudhuin, P., Opperdoes, F.R. &
Courtoy, P.J. (1992) Receptor-mediated endocytosis in Trypanosoma
brucei. 2nd European Workshop on Endocytosis, Paris, 1-5 October,
1990, NATO ASI Series, vol H62, "Endocytosis, from Cell Biology to
Health, Disease and Therapy (P.J. Courtoy, ed.), Springer-Verlag
Berlin Heidelberg, 475-480.
- Coppens, I., Ter Kuile, B.H. & Opperdoes, F.R. (1992)
Growth impairment of Leishmania donovani by Trypanosoma brucei
during coculture. Parasitology,
105, 393-398.
- Gaspar, R., Préat, V., Opperdoes, F.R. & Roland, M.
(1992) Macrophage activation by polymeric nanoparticles of
polyalkylcyanoacrylates: activity against intracellular Leishmania
donovani associated with hydrogen peroxide production. Pharmaceutical
Res., 9, 782-787.
- Gaspar, R., Opperdoes, F.R., Préat, V. & Roland, M.
(1992) Drug targeting with polyalkylcyanoacrylates nanoparticles:
in vitro activity of primaquine-loaded nanoparticles against
intracellular Leishmania donovani. Ann.
Trop. Med. Parasitol., 86, 41-49.
- Hannaert, V., Blaauw, M., Kohl, L., Allert, S., Opperdoes,
F.R. & Michels, P.A.M. (1992) Molecular analysis of the
cytosolic and glycosomal glyceraldehyde-3-phosphate dehydrogenase
in Leishmania mexicana. Mol.
Biochem. Parasitol., 55, 115-126.
- Kessler, H., Matter, H., Geyer, A., Diehl, H.-J., Köck,
M., Kurz, G., Opperdoes, F.R., Callens, M. & Wierenga, R.K.
(1992) Selective inhibition of trypanosomal triosephosphate
isomerase by a thiopeptide. Angew. Chem. Int. Ed. Engl., 31,
328-330.
- Kuntz, D.A., Osowski, R., Schudok, M., Wierenga, R.K., Muller,
K., Kessler, H. & Opperdoes, F.R. (1992) Inhibition of
triosephosphate isomerase from Trypanosoma brucei with cyclic
hexapeptides. Eur.
J. Biochem., 207, 441-447.
- Michels, P.A.M., Opperdoes, F.R., Hannaert, V., Wiemer,
E.A.C., Allert, S. & Chevalier, N. (1992) Phylogenetic
analysis based on glycolytic enzymes. Belg. J. Bot., 125,
164-173.
- Rayyan, W., Kuntz, D.A., Opperdoes, F.R. & Hoet, P.P.
(1992) Expression in Bacillus subtilis of the glycosomal
glyceraldehyde-phosphate dehydrogenase gene from Trypanosoma
brucei. Biochimie,
74, 137-141.
- Sanchez-Moreno, M., Lasztity, D., Coppens, I. & Opperdoes,
F.R. (1992) Characterization of carbohydrate metabolism and
demonstration of glycosomes in a Phytomonas sp. isolated from
Euphorbia characias. Mol.
Biochem. Parasitol., 54, 185-200.
- Swinkels, B.W., Loiseau, A., Opperdoes, F.R., Veenhuis, M.
& Borst, P. (1992) A phosphoglycerate kinase related gene,
conserved between Trypanosoma brucei and Crithidia fasciculata,
encodes a glycosomal (microbody) protein. Mol.
Biochem. Parasitol., 50, 69-78.
- Ter Kuile, B.H. & Opperdoes, F.R. (1992) A chemostat study
on proline uptake and metabolism of Leishmania donovani. J.
Protozool., 39, 555-558.
- Ter Kuile, B.H. & Opperdoes, F.R. (1992) Mutual adjustment
of glucose uptake and metabolism in Trypanosoma brucei grown in
the chemostat. J.
Bacteriol., 174, 1273-1279.
- Ter Kuile, B.H. & Opperdoes, F.R. (1992) Comparative
physiology of two protozoan parasites grown in chemostats,
Leishmania donovani and Trypanosoma brucei. J.
Bacteriol., 174, 2929-2934.
- Ter Kuile, B.H., Wiemer, E.A.C., Michels, P.A.M &
Opperdoes, F.R. (1992) The electrochemical proton gradient in the
bloodstream form of Trypanosoma brucei is dependent on the
temperature. Mol.
Biochem. Parasitol., 55, 21-28.
- Verlinde, C.L.M.J., Witmans, C.J., Pijning, T., Kalk, K.H.,
Hol, W.G.J., Callens, M. & Opperdoes, F.R. (1992) Structure of
the complex between trypanosomal triosephosphate isomerase and
N-hydroxy-4-phosphono-butanamide: binding at the active site
despite an "open" flexible loop conformation. Protein
Science, 1, 1578-1584.
- Wiemer, E.A.C., Ter Kuile, B.H., Michels, P.A.M. &
Opperdoes, F.R. (1992) Pyruvate transport across the plasma
membrane of the bloodstream form of Trypanosoma brucei is mediated
by a facilitated diffusion carrier. Biochem.
Biophys. Res. Comm., 184, 1028-1034.
- Willson, M., Périé, J.J., Malecaze, F.,
Opperdoes, F.R. & Callens, M. (1992) Biological properties of
amidinium sulfinic and sulfonic acid derivatives: inhibition of
glycolytic enzymes from Trypanosoma brucei and protective effect
on cell growth. Eur. J. Med. Chem., 27, 799-808.
Top
1993
- Borchert, T.V., Pratt, K., Zeelen, J.Ph., Callens, M., Noble,
M.E.M., Opperdoes, F.R., Michels, P.A.M. & Wierenga, R.K.
(1993) Overexpression of trypanosomal triosephosphate isomerase in
Escherichia coli and characterization of a dimer interface mutant.
Eur.
J. Biochem., 211, 703-710.
- Callens, M., Van Roy, J., Zeelen, J.Ph., Borchert, T.V.,
Nalis, D., Wierenga, R.K. & Opperdoes, F.R. (1993) Selective
interaction of glycosomal enzymes from Trypanosoma brucei with
hydrophobic cyclic hexapeptides. Biochem.
Biophys. Res. Commun., 195, 667-672.
- Coppens, I., Baudhuin, P., Opperdoes, F.R. & Courtoy,
P.J.(1993) Role of acidic compartments in Trypanosoma brucei, with
special reference to LDL processing. Mol.
Biochem. Parasitol., 58, 223-232.
- Opperdoes, F.R. & Michels, P.A.M. (1993) The glycosomes of
the Kinetoplastida. Biochimie,
75, 231-234.
- Opperdoes, F.R. (1993) Strijders tegen slaapziekte rusten
niet. Chemisch Magazine, 9, 356.
- Opperdoes, F.R. (1993) Tropische ziekten en geneesmiddelen.
Focus Diagnostica, 1, 14-15.
- Perié, J., Rivière-Alric, I., Blonski, C.,
Gefflaut, Th., Lauth de Viguerie, N., Trinquier, M., Willson, M.,
Opperdoes, F.R. & Callens, M. (1993) Inhibition of the
glycolytic enzymes in the trypanosome: an approach in the
development of new leads in the therapy of parasitic diseases.
Pharmac.
Therm., 60, 347-365.
- Ter Kuile, B.H. & Opperdoes, F.R. (1993) Leishmania
donovani accumulates glucose by conversion into trehalose rather
than by active transport. Mol.
Biochem. Parasitol, 60, 313-322.
- Van Sterkenburg, E.L.M., Coppens, I., Wilting, J., Bos,
O.J.M., Fischer, M.J.E., Janssen, L.H.M. & Opperdoes, F.R.
(1993) The uptake of the trypanocidal drug suramin in combination
with low-density lipoproteins by Trypanosoma brucei and its
possible mode of action. Acta
Tropica, 54, 237-250.
- Verlinde, C.L.M.J., Pijning, J., Kalk, K.H., Van Calenbergh,
S., Van Aerschot, A., Herdewijn, P., Callens, M., Michels, P.,
Opperdoes, F.R., Wierenga, R.K. & Hol, W.G.J. (1993) Protein
structure-based inhibitor design: towards new drugs for the
treatment of sleeping sickness. Perspect.Med. Chem., 1 (Testa, B.,
ed.), 135-148.
- Willson, M., Callens, M., Kuntz, D., Perié, J. &
Opperdoes, F.R. (1993) Synthesis and activity of anti-hot-spot
inhibitors specific for the glycolytic enzymes from Trypanosoma
brucei. Mol.
Biochem. Parasitol., 59, 201-210.
Top
1994
- Bastin, Ph., Coppens, I., Saint-Rémy, J.-M., Baudhuin,
P., Opperdoes, F.R. & Courtoy, P.J. (1994) Identification of a
specific epitope on the extracellular domain of the LDL-receptor
of Trypanosoma brucei brucei. Mol.
Biochem. Parasitol., 63, 193-202.
- Blum, J.J. & Opperdoes, F.R. (1994) Secretion of sucrase
by Leishmania donovani. J.
Eukaryotic Microbiology, 41, 228-231.
- Buxbaum, L.U., Raper, J., Opperdoes, F.R. & Englund, P.T.
(1994) Myristate exchange: a second glycosyl phosphatidylinositol
myristoylation reaction in African trypanosomes. J.
Biol. Cell, 269, 30212-30220.
- Chaumont, F., Schanck, A.N., Blum, J.J. & Opperdoes, F.R.
(1994) Aerobic and anaerobic glucose metabolism of Phytomonas sp.
isolated from Euphorbia characias. Mol.
Biochem. Parasitol., 67, 321-331.
- Ernest, I., Callens, M., Opperdoes, F.R. & Michels, P.A.M.
(1994) Pyruvate kinase of Leishmania mexicana mexicana. Cloning
and analysis of the gene, overexpression in Escherichia coli and
characterization of the enzyme. Mol.
Biochem. Parasitol., 64, 43-54.
- Ernest, I., Opperdoes, F.R. & Michels, P.A.M. (1994)
Cloning and sequence analysis of the gene encoding pyruvate kinase
in Trypanoplasma borelli. Biochem.
Biophys. Res. Commun., 201, 727-732.
- Hannaert, V., Callens, M., Opperdoes, F.R. & Michels,
P.A.M. (1994) Purification and characterization of the native and
the recombinant Leishmania mexicana glycosomal
glyceraldehyde-3-phosphate dehydrogenase. Eur.
J. Biochem., 225, 143-149.
- Kohl, L., Callens, M., Wierenga, R.K., Opperdoes, F.R. &
Michels, P.A.M. (1994) Triosephosphate isomerase of Leishmania
mexicana mexicana. Cloning and characterization of the gene,
overexpression in Escherichia coli and analysis of the protein.
Eur.
J. Biochem., 220, 331-338.
- Lukes, J., Arts, G.J., van den Burg, J., de Haan, A.,
Opperdoes, F., Sloof, P. & Benne, R. (1994) Novel pattern of
editing regions in mitochondrial transcripts of the cryptobiid
Trypanoplasma borreli. EMBO
J., 13, 5086-5098.
- Nyame, K., Do-Thi, C.D., Opperdoes, F.R. & Michels, P.A.M.
(1994) Subcellular distribution and characterization of
glucosephosphate isomerase in Leishmania mexicana mexicana.
Mol.
Biochem. Parasitol., 67, 269-279.
- Opperdoes, F.R. (1994) The Trypanosomatidae: amazing
organisms. J.
Bioenerg. Biomembr., 26, 145-146.
- Prado-Figueroa, M., Raper, J. & Opperdoes, F.R. (1994)
Possible localization of dolichol-dependent mannosyltransferase of
Trypanosoma brucei to the endoplasmic reticulum. Mol.
Biochem. Parasitol., 63, 255-264.
- Verlinde, C.L.M.J., Callens, M., Van Calenbergh, S., Van
Aerschot, A., Herdewijn, P., Hannaert, V., Michels, P., Opperdoes,
F.R. & Hol, W.G.J. (1994) Protein structure-based design for
selective inhibition of trypanosomal glyceraldehyde-3-phosphate
dehydrogenase: towards new drugs for the treatment of sleeping
sickness. J.
Med. Chem., 37, 3605-3613.
- Willson, M., Lauth, N., Périé, J., Callens, M.
& Opperdoes, F.R. (1994) Inhibition of
glyceraldehyde-3-phosphate dehydrogenase by phosphorylated
epoxides and alpha-enones. Biochemistry,
33, 214-220.
Top
1995
- Hannaert, V., Opperdoes, F.R. & Michels, P.A.M. (1995)
Glycosomal glyceraldehyde-3-phosphate dehydrogenase of Trypanosoma
brucei and Trypanosoma cruzi: expression in Escherichia coli,
purification and characterization of the enzymes. Protein
Expression and Purification, 6, 244-250.
- Opperdoes, F.R. (1995) Carbohydrate and energy metabolism of
aerobic protozoa. In: Biochemistry and molecular biology of
parasites (J.J. Marr and M. Müller, eds), Academic Press,
London, pp. 19-32.
- Opperdoes, F.R. (1995) Conception rationnelle de nouveaux
médicaments contre la maladie du sommeil.
Médecine/Sciences, 11, 1305-1313.
- Sanchez-Moreno, M., Monestier, A., Fernandez-Becerra, C.,
Lopez-Gay, J., Opperdoes, F.R. & Osuna, A. (1995) In vitro
culture of Phytomonas sp. isolated from Euphorbia characias.
Metabolic studies by 1H NMR. J. Eukaryotic. Microbiol., 42,
314-320.
- Trinquier, M., Perié, J., Opperdoes, F.R., Callens, M.
& Willson, M. (1995) Specific inhibitors for the glycolytic
enzymes of Trypanosoma brucei. Biorganic
and Medicinal Chemistry, 3, 1423-1427.
- Wiemer, E., Michels, P.A.M. & Opperdoes,F.R. (1995) The
inhibition of pyruvate transport across the plasma membrane of the
Trypanosoma brucei bloodstream form and its metabolic
implications. Biochem.
J., 312, 479-484.
- Wiemer, E.A.C., Hannaert, V., van den IJssel, P.R.L.A., Van
Roy, J., Opperdoes, F.R. & Michels, P.A.M. (1995) Molecular
analysis of glyceraldehyde-3-phosphate dehydrogenase in
Trypanoplasma borelli. An evolutionary scenario of subcellular
compartmentation in Kinetoplastida. J.
Mol. Evol., 40, 443-454.
- Zomer, A.W.M., Opperdoes, F.R. & van den Bosch, H. (1995)
Alkyl dihydroxyacetone phosphate synthase in glycosomes of
Trypanosoma brucei. Biochim.
Biophys. Acta, 1257, 167-173.
Top
1996
- Bastin, Ph., Stephan, A., Raper, J., Saint-Rémy, J.-M.,
Opperdoes, F.R. & Courtoy, P.J. (1996) An Mr 145,000
low-density lipoprotein (LDL)-binding protein is conserved
throughout the Kinetoplastida order. Mol.
Biochem. Parasitol., 76, 43-56.
- Kohl, L., Drmota, T., Do Thi, C.-D., Callens, M., Van Beeumen,
J., Opperdoes, F.R. & Michels, P.A.M. (1996) Cloning and
characterization of the NAD-linked glycerol-3-phosphate
dehydrogenase of Trypanosoma brucei and Leishmania mexicana and
expression of the trypanosomal protein in Escherichia coli.
Mol.
Biochem. Parasitol., 76, 159-173.
- Wiemer, E.A.C., IJlst, L., Van Roy, J., Wanders, J.A. &
Opperdoes, F.R. (1996) Identification of 2-enoyl coenzyme A
hydratase and NADP+-dependent 3-hydroxyacyl-CoA dehydrogenase
activity in glycosomes of procyclic Trypanosoma brucei. Mol.
Biochem. Parasitol., 82, 107-111.
Top
1997
- Adjé C.A., Opperdoes F.R., & Michels P.A.M. (1997)
Organization, sequence and stage-specific expression of the
phosphoglycerate kinase genes of Leishmania mexicana
mexicana. Mol
Biochem Parasitol, 90, 155-168.
- Bakker, B.M., Michels, P.A.M., Opperdoes, F.R., &
Westerhoff, H.V. (1997) Glycolysis in bloodstream form Trypanosoma
brucei can be understood in terms of the kinetics of the
glycolytic enzymes. J
Biol Chem 272, 3207-3215.
- Fernandez-Becerra, C., Sanchez-Moreno, M., Osuna, A.,&
Opperdoes, F.R. (1997) Comparative aspects of energy metabolism in
plant trypanosomatids. J Eukar Microbiol. , 44, 523-529.
- Heise, N, & Opperdoes, F.R. The dihydroxyacetonephosphate
pathway for biosynthesis of ether lipids in Leishmania mexicana
promastigotes. Mol
Biochem Parasitol. 89, 61-72.
- Michels, P.A.M., Chevalier, N., Opperdoes, F.R., Rider, M.H.
& Rigden D.J. (1997) The glycosomal ATP-dependent
phosphofructokinase of Trypanosoma brucei must have evolved
from an ancestral pyrophosphate-dependent enzyme. Eur.
J. Biochem., 250, 698-704.
- Uttaro, A.D, & Opperdoes, F.R. (1997) Purification and
characterisation of a novel iso-propanol dehydrogenase from
Phytomonas sp. Mol
Biochem Parasitol. 85:213-219
- Uttaro, A.D. & Opperdoes, F.R. (1997) Characterisation of
the two malate dehydrogenases from Phytomonas sp.
Purification of the glycosomal isoenzyme. Mol
Biochem Parasitol, 89, 51-59.
- Uttaro A.D., Sanchez-Moreno, M. & Opperdoes,
F.R. (1997) Genus-specific
biochemical markers for Phytomonas spp. Mol
Biochem Parasitol., 90, 337-342.
Top
1998
- Adjé, C., Opperdoes, F.R. & Michels, P.A.M. (1998)
Molecular analysis of phosphoglycerate kinase in Trypanoplasma
borreli and the evolution of this enzyme in Kinetoplastida.
Gene,
217, 91-99
- Bakker, B.M., Mensonides, F.I.C., ter Kuile, B.H., Michels,
P.A.M., Opperdoes, F.R.,Westerhoff, H.V. and Walsh, M.C. (1998)
Metabolic control analysis reveals that glucose transport
incompletely controls the glycolytic flux in Trypanosoma brucei.
In: BioThermoKinetics in the Post Genomic Era (Larsson, C.,
Pahlman, I. and Gustafsson, L., Eds.), Goteborg, pp. 66-70.
- Clayton, C. et al., Michels, P.A.M. et al., Opperdoes, F.R. et
al. & Vanhamme, L. (1998) Genetic nomenclature for Trypanosoma
and Leishmania. Mol. Biochem. Parasitol., 97, 221-224
- Ernest, I., Callens, M., Uttaro, A.D., Chevalier, N.,
Opperdoes, F.R., Muirhead, H., & Michels, P.A.M. (1998)
Pyruvate kinase of Trypanosoma brucei:
overexpression, purification and functional characterization of
wild-type and mutated enzyme. Protein
Expression and Purification, 13, 373-382
- Hannaert, V., Opperdoes, F.R. & Michels, P.A.M. (1998)
Comparison of the glycosomal glyceraldehyde-3-phosphate
dehydrogenase from different Kinetoplastida. J.
Mol. Evol. 47, 728-738.
- Opperdoes, F.R. (1998) Carbohydrate metabolism. Human African
Trypanosomiasis (Bouteille, B. and Dumas, M, Editors), Chapter 4,
61-93.
- Opperdoes, F.R., Michels, P., Adjé, Ch., &
Hannaert, V. (1998) Organelle and enzyme evolution in
trypanosomatids. Chapter in "Evolutionary Relationships among
Protozoa", (Eds, Coombs, G.H., Vickerman, K., Sleigh, M.A. and
Warren, A.), Chapman and Hall, London, pp. 229-253.
- Van Hellemond, J.J., Opperdoes, F.R. & Tielens, A.G.M.
(1998) Trypanosomatidae produce acetate via a mitochondrial
acetate:succinate CoA-transferase. Proc.
Nat. Acad. Sci. USA, 95, 3036-3041
- Zomer, A.W.M., Allert, S., Chevalier, N., Callens, M.,
Opperdoes, F.R. & Michels, P.A.M. (1998) Purification and
characterisation of the phosphoglycerate kinase isoenzymes of
Trypanosoma brucei expressed in Escherichia coli.
Biochim.
Biophys. Acta, 1386, 179-188
Top
1999
- Aronov, A.M., Suresh, S., Buckner, F.S., Van Voorhis, W.C.,
Verlinde, C.L.M.J., Opperdoes, F.R., Hol, W.G.J. and Gelb, M.H.
(1999) Structure-based design of sub-micromolar, biologically
active inhibitors of trypanosomatid glyceraldehyde-3-phosphate
dehydrogenase. Proc.
Natl. Acad. Sci. USA, 96, 4273-4278
- Bakker, B.M., Michels, P.A.M., Opperdoes, F.R. and Westerhoff,
H.V. (1999) What controls glycolysis in bloodstream form
Trypanosoma brucei ? J.
Biol. Chem., 274, 14551-14559
- Bakker, B.M., Walsh, M.C., Ter Kuile, B.H., Mensonides,
F.I.C., Michels, P.A.M., Opperdoes, F.R. and Westerhoff, H.V.
(1999) Contribution of glucose transport to the control of the
glycolytic flux in Trypanosoma brucei.. Proc.
Natl. Acad. Sci. USA, 96, 10098-10103
- de Walque, S., Kiel, J.A.K.W., Veenhuis, M., Opperdoes, F.R.
and Michels, P.A.M. (1999) Cloning and analysis of the PTS-1
receptor in Trypanosoma brucei. Mol.
Biochem. Parasitol., 104, 107-119
- de Walque, S., Opperdoes, F.R. and Michels, P.A.M. (1999)
Cloning and characterization of Leishmania mexicana
fructose-1,6-bisphosphate aldolase. Mol.
Biochem. Parasitol., 103, 279-283
- Heise, N. & Opperdoes, F.R. (1999) Purification,
localisation and characterisation of glucose-6-phosphate
dehydrogenase from Trypanosoma brucei. Mol.
Biochem. Parasitol., 99, 21-32
- Zomer, A.W.M., Michels, P.A.M. & Opperdoes, F.R. (1999)
Molecular characterisation of Trypanosoma brucei alkyl
dihydroxyacetone-phosphate synthase. Mol.
Biochem. Parasitol., 104, 55-66
Top
2000
- Bakker, B., Westerhoff, H.V., Opperdoes, F.R. & Michels,
P.A.M. (2000) Metabolic control analysis as an approach to improve
selectivity and effectiveness of drugs. Mol.
Biochem. Parasitol., 106, 1-10I.
- Bakker, B.M., Michels, P.A.M., Walsh,M.C., Opperdoes, F.R.
& Westerhoff, H.V. (2000) Using metabolic control analysis to
improve the selectivity and effectiveness of drugs against
parasitic diseases. In: Technological and Medical Implications of
Metabolic Control Analysis (Cornish-Bowden, A.J. & Cardenas,
M.L., eds), Kluwer Academic Publishers, Dordrecht, Chapter 17, pp.
157-164
- Chevalier, N., Rigden, D.J., Van Roy, J., Opperdoes, F.R.
& Michels, P.A.M. (2000) Trypanosoma brucei contains a
2,3-bisphosphoglycerate-independent phosphoglycerate mutase.
Eur.
J. Biochem., 267, 1464-1472
- Duffieux, F., Van Roy, J., Michels, P.A.M. & Opperdoes,
F.R. (2000)Molecular characterization of the first two enzymes of
the pentose-phosphate pathway of Trypanosoma brucei. J.
Biol. Chem., 275, 27559-27565.
- Hardré, R., Salmon, L. & Opperdoes, F.R. (2000)
Competitive inhibition of Trypanosoma brucei phosphoglucose
isomerase by D-arabinose-5-phosphate derivatives. J.
Enzyme Inhibition, 15, 509-515.
- N. Heise & F.R. Opperdoes. (2000) Localisation of a major
soluble 3-hydroxy-3-methylglutaryl-coenzyme A reductase in the
mitochondrial matrix of Trypanosoma brucei procyclics. Zeitschrift
für Naturforschung, 55c, 473-477
- Kralova, I., Rigden, D.J., Opperdoes, F.R. & Michels,
P.A.M. (2000) Glycerol kinase of Trypanosoma brucei: cloning,
molecular characterization and mutagenesis. Eur.
J. Biochem., 267, 2323-2333
- Lux, H., Heise, N., Klenner, T., Hart, D. & Opperdoes,
F.R. (2000) Ether-lipid (alkylphospholipid) metabolism and the
mechanism of action of ether-lipid analogues in Leishmania.
Mol.
Biochem. Parasitol., 111, 1-14.
- Marché, S., Michels, P.A.M. & Opperdoes, F.R.
(2000) Comparative study of Leishmania mexicana and Trypanosoma
brucei NAD-dependent glycerol-3-phosphate dehydrogenase. Mol.
Biochem. Parasitol., 106, 83-91
- Michels, P.A.M., Bakker, B.M., Opperdoes, F.R. &
Westerhoff, H.V. (2000) On the mathematical modelling of metabolic
pathways and its use in the identification of the most suitable
drug target. In: Tropical disease guidelines and issues:
discoveries and drug development (eds. H. Vial, A. Fairlamb and R.
Ridley), WHO publisher, Geneva, in press
- Opperdoes, F.R. (2000) Phylogenetic analyses using protein
sequences. In: Phylogenetic Analysis in Practice (Salemi, M. and
Vandamme A.-M., eds), Cambridge University Press, Sixth European
Workshop on Virus Evolution and Molecular Epidemiology, Rega
Institute for Medical Research, Leuven, September 4-8, 2000
- Suresh, S., Turley, S., Opperdoes, F.R., Michels, P.A.M. &
Hol, W.G.J. (2000) Crystal structure of NAD-dependent
glycerol-3-phosphate dehydrogenase from Leishmania mexicana: a
potential target enzyme for trypanocidal drugs. Struct.
Fold. Dis., 8, 541-552.
- Uttaro, A.D., Altabe, S.G., Rider, M.H., Michels, P.A.M. &
Opperdoes, F.R. (2000) A family of highly conserved glycosomal
2-hydroxyacid dehydrogenases from Phytomonas sp. J.
Biol. Chem., 275, 31833-31837.
Top
2001
- Miclet, E., Stoven, V., Michels, P.A.M., Opperdoes, F.R.,
Lallemand, J.-Y. & Duffieux, F. (2001) NMR spectroscopic
analysis of the first two steps of the pentose-phosphate pathway
elucidates the role of 6-phosphogluconolactonase. J.
Biol. Chem., 276, 34840-34846.
- Opperdoes, F.R. & Michels, P.A.M. (2001) Enzymes of
carbohydrate metabolism as potential drug targets. Int.
J. Parasitol., 31, 482-490.
- Verlinde, C.L.M.J., Hannaert, V., Blonski, C., Willson, M.,
Périé, J.J., Fothergill-Gilmore, L.A., Opperdoes,
F.R., Gelb, M.H., Hol, W.G.J. & Michels, P.A.M. (2001)
Glycolysis as a target for the design of new anti-trypanosome
drugs. Drug
Resistance Updates, 4, 50-65.
Top
2002
- Foultier, B., Troisfontaines, P., Müller, S., Opperdoes,
F.R. and Cornelis, G.R.(2002) Characterization of the ysa
pathogenicity locus in the chromosome of Yersinia enterocolitica
and phylogeny analysis of type III secretion systems. J
Molec Evolution 55, 37-51, 2002.
- Hannaert, V., Saavedra, E., Duffieux, F., Szikora, J.-P.,
Rigden, D.J., Michels, P.A.M. and Opperdoes, F.R. (2002)
Plant-like traits associated with metabolism in Trypanosomatid
parasites. Proc.Natl.Acad.Sc. USA., in press
- Hannaert, V., Yernaux, C., Rigden, D.J., Fothergill-Gilmore,
L.A., Opperdoes, F.R. and Michels, P.A.M. (2002) The putative
effector-binding site of Leishmania mexicana pyruvate kinase
studied by site-directed mutagenesis. FEBS
Lett., 514, 255-259.
- Willson, M., Sanejouand, Y.-H., Périé, J.,
Hannaert, V. and Opperdoes, F.R. (2002) Sequencing, modeling and
selective inhibition of Trypanosoma brucei hexokinase. Chem
Biol 9, 839-847, 2002.
Top
2003
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Last updated: 19 February, 2002.
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