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Analysis of the metabolic capacities
of trypanosomatids. |
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Bioinformatics analysis of all predicted protein sequences
allowed to obtain an idea of the glycosomal proteome of
trypanosomatids. Predictions based on the presence of glycosomal
import signals of type 1 and type 2 (PTS1 and PTS2) were
confirlmed (or not) by proteomic analysis of glycosomal
fractions. Some interesting observations are that in addition
to carbohydrate metabolism glycosomes are involved in fatty
acid oxidation, ether-lipid synthesis, pyrimidine synthesis,
protections against oxidant stress.
People involved in the subject:
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Fred Opperdoes
- Paul Michels
- Jean-Pierre Szikora
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TriTryp genome project
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Vertommen D, Van Roy
J, Szikora JP, Rider MH, Michels PA, Opperdoes FR. Differential
expression of glycosomal and mitochondrial proteins
in the two major life-cycle stages of Trypanosoma brucei.
Mol Biochem Parasitol. 2008 Apr;158(2):189-201.
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Rosenzweig D, Smith D,
Opperdoes F, Stern S, Olafson RW, Zilberstein D. Retooling
Leishmania metabolism: from sand fly gut to human macrophage.
FASEB J. 2008 Feb;22(2):590-602.
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Opperdoes FR, Michels
PA. Horizontal gene transfer in trypanosomatids. Trends
Parasitol. 2007 Oct;23(10):470-6. Epub 2007 Sep 7.
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Opperdoes FR, Coombs
GH. Metabolism of Leishmania: proven and predicted.
Trends Parasitol. 2007 Apr;23(4):149-58. Epub 2007 Feb
22. Review.
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Opperdoes FR, Szikora
JP. In silico prediction of the glycosomal enzymes of
Leishmania major and trypanosomes. Mol Biochem Parasitol.
2006 Jun;147(2):193-206.
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