COST
ACTION B22
DRUG
DEVELOPMENT FOR PARASITIC DISEASES
COST B22 WG5: Drug Resistance
Venue
University of Glasgow,
Glasgow, Scotland, UK
G12 8QQ
Local organisers
Professor
Graham H. COOMBS
Infection
& Immunity
Joseph
Black Building
University
of Glasgow
UK - G12 8QQ Glasgow
Tel: +44 141 330 4777
Fax: +44 141 330 3516
E-mail: g.coombs@bio.gla.ac.uk
Dr
Michael P. BARRETT
Infection
& Immunity
Joseph
Black Building
University
of Glasgow
UK - G12 8QQ Glasgow
Tel: +44 141 330 4777
Fax: +44 141 330 3516
E-mail: m.barrett@bio.gla.ac.uk
DATE
11Ð 12 July 2005
COST B22 WG5: Drug Resistance
PROGRAMME
Monday 11th July
2005
0900 h:
Opening of Meeting
0910 h. Session
1: Leishmania (Chair: Coombs)
- 0910-0945 h: Dujardin (Belgium) Review on
occurrence of drug resistance.
- 0945-1005 h: Yardley (London, UK) The sensitivity
of different species to drugs
- 1005-1025 h: Scoulica (Greece) Methods for determining drug sensitivity
- 10025-1045 h: Sereno (France) Use of in vitro culture of amastigotes for analysing
drug sensitivity mechanisms
1045-1105 h:
Discussions and Refreshment Break
- 1105-1140 h: Edwards (Durham, UK) Occurrence
and mechanisms of, and ways of avoiding/overcoming, herbicide resistance
- 1140-1200 h: Mukhopadhyay (USA) Transporters of Leishmania in resistance to antimonials
- 1200-1220 h: Zilberstein (Israel) Analysis of L. donovani amastigotes for drug sensitivity
- 1220-1240 h: Madhubala (India) Analysis of antimonial
drug resistance in field isolates of L. donovani
- 1240-1250 h: Decuypere (Belgium) Investigating markers for
drug resistance
1250-1350 h:
Discussions and Buffet Lunch
- 1350-1410 h: Gamarro (Spain) Leishmania sensitivity to miltefosine depends on
drug uptake mechanisms
- 1410-1420 h: Burchmore (Glasgow, UK) Proteomic
approaches to analysing mechanisms of drug resistance
- 1420-1440 h: Carter (Strathclyde, UK) Role of
glutathione metabolism in drug resistance
- 1440-1500 h: Ulrich (Germany) Methodology for analysing
conversion of SbV to SbIII.
- 1500-1535 h: Brown (Beatson, Glasgow, UK) Occurrence
and mechanisms of, and ways of avoiding/overcoming, anticancer drug
resistance
1535-1555 h:
Discussion and Refreshment Break
1555 h. Session 2: Apicomplexan parasites
(Chair: Barrett)
- 1555-1630 h: Ward (UK) Review on occurrence of drug
resistance.
- 1630-1650 h: Ranford-Cartwright (Glasgow, UK)
Frequency and spread of antimalarial drug resistance in Africa.
- 1650-1710 h: Cravo (Portugal) Stable and transmissible artemisinin
resistance in malaria parasites
- 1710-1730 h: Krishna (UK) New ideas about
chloroquine and artemisinin resistance in malaria
- 1730-1750 h: Ginsburg (Israel) Should chloroquine
be laid to rest?
1800-1900
h. Reception at the University Art Gallery
1930 h:
Refreshments and Dinner
Tuesday 12th July 2005
0900 h. Session 2 (continued): Apicomplexan
parasites (Chair: Barrett)
- 0900-0920 h: Lanzer (Germany) Biochemical
evidence for a chloroquine efflux system
- 0920-0940 h: Bray (UK) PfCRT in malarial chloroquine
resistance: pump or leak?
- 0940-1000 h: Vial (France) Resistance to novel
antimalarials
- 1000-1035 h: Trieu-Cuot (France) Occurrence
and mechanisms of, and ways of avoiding/overcoming, antibacterial drug
resistance
1035-1055 h:
Discussions and Refreshment Break
1055 h. Session
3: African trypanosomes:
(Chair: Krishna)
- 1055-1130 h: Barrett (UK) Review on occurrence of drug
resistance
- 1130-1145 h: Atouguia (Portugal) HAT - Clinical problems in
the field
- 1145-1205 h: Delespaux (Belgium) Isometamidium resistance in T.
congolense
- 1205-1225 h: MacLeod (Glasgow, UK) Genetic
analysis of drug resistance
- 1225-1300 h: Roos (Netherlands) Occurrence and mechanisms of,
and ways of avoiding/overcoming, anthelmintic drug resistance
1300-1400 h:
Discussions and Buffet Lunch
- 1400-1420 h: Mþser (Switzerland) Adenosine transport and
drug resistance in Trypanosoma brucei
- 1420-1440 h: de Koning (UK) Cross-resistance
patterns for diamidines and melaminophenyl arsenicals in African
trypanosomes
- 1440-1500 h: Seebeck (Switzerland) Multidrug resistance transporters -
major players in signal transduction
- 1500-1510 h: Luescher (Switzerland) The role of
transport and metabolism in drug resistance
1510-1530 h:
Discussions and Refreshment Break
1530 h. Session
4: Trichomonads, Giardia: (Chair: Coombs)
- 1520-1555 h: Kulda (Czech Republic) Review on
occurrence of drug resistance
- 1555-1615 h: Hrdy (Czech Republic) How drug
resistance and susceptible lines of Trichomonas differ
- 1615-1650 h: Rohwer (Germany) Occurrence and
mechanisms of, and ways of avoiding/overcoming, resistance of
ectoparasites and insect vectors to drugs
1650-1730
h: Closing discussion and recommendations.
Discussants: MŸller
(Glasgow, UK), Tittawella (Sweden)
Woodrow (London, UK)
1730 h:
Discussions, Refreshments and Dinner
2200 h.
Close of Meeting
Wednesday 13 July 2005
Depart
| List of Participants |
 |
Jorge Atouguia
Jorge Instituto de Higiena e Medicina
Tropical,
Universidade Nova de Lisboa,
Lisbon, Portugal.
JMA@ihmt.unl.pt
Michael P. Barrett
Division of Infection & Immunity
Institute of Biomedical and Life Sciences
Joseph Black Building
University of Glasgow
GLASGOW G12 8QQ
tel & FAX (+44)-141-330-6904
m.barrett@bio.gla.ac.uk
Patrick Bray
Molecular & Biochemical Parasitology
Group
Liverpool School of Tropical Medicine
Liverpool L3 5QA
United Kingdom
p.g.bray@liverpool.ac.uk
Bob Brown
Centre for Oncology & Applied
Pharmacology
CRUK Beatson Labs, Glasgow University
Glasgow G61 1BD
R.Brown@beatson.gla.ac.uk
Richard Burchmore
Sir Henry Wellcome Functional Genomics Facility
Institute of Biomedical and Life Sciences
University of Glasgow
Glasgow G12 8QQ
United Kingdom
tel: (+44) 141 330 8612
FAX: (+44) 141 330 4600
r.burchmore@bio.gla.ac.uk
Chris Carter
Department of Immunology,
University of Strathclyde,
Glasgow G4 0NR,
United Kingdom.
Tel: 0141-548-3823/3748
(direct)
0141-552-4400
ext 3823 (switchboard)
0141-548-3748
(secretary)
Fax:
0141-548-3427
Graham H. Coombs
Infection & Immunity
Joseph Black Building
University of Glasgow
Glasgow G12 8QQ
UK
tel: ++ 44 141 330 4777
fax: ++ 44 141 330 3516
g.coombs@bio.gla.ac.uk
Pedro Vitor Cravo
Jorge Instituto de Higiena e Medicina
Tropical,
Universidade Nova de Lisboa,
Lisbon, Portugal.
PCravo@ihmt.unl.pt
Saskia Decuypere
Department of Parasitology
Unit of Molecular Parasitology
Prince Leopold Institute of Tropical
Medicine
Nationalestraat 155
B-2000 Antwerpen
Belgium
Tel: +32 3 2476586
Fax: +32 3 2476359
Harry de Koning
Institute of Biomedical and Life Sciences
Division of Infection and Immunity
University of Glasgow
Joseph Black Building, North Lab.
Glasgow G12 8QQ
UK
Tel 0141-330 3753
Fax 0141-330 3753
H.de-Koning@bio.gla.ac.uk
Vincent Delespaux
Trypanosomosis Unit
Department of Animal Health
Institute of Tropical Medicine Antwerpen
Nationalestraat 155, B-2000 - Antwerpen
Phone: +33 3 247 63 90 Fax:32 3 2476268
E-mail: vdelespaux@itg.be
J.-C. Dujardin
Department of Parasitology
Unit of Molecular Parasitology
Prince Leopold Institute of Tropical
Medicine
Nationalestraat 155
B-2000 Antwerpen
Belgium
J.-C. Dujardin
[JCDujardin@itg.be]
Robert
Edwards
School
of Biological and Biomedical Sciences,
University of Durham,
South Road, Durham DH1 3LE, UK
Phone +44-191 334 1318
FAX +44-191 334 1201
Francisco Gamarro
Instituto de Parasitologia y Biomedicina "Lopez-Neyra"
Departamento de Bioqu’mica y Farmacolog’a Molecular,
Parque Tecnol—gico de Ciencias de la Salud
Avda. del Conocimiento, s/n,
18100 Armilla, GRANADA.
(SPAIN)
Phone 34-958-181667 / 34-958-181621, ext 544
Fax: 34-958-181633
gamarro@ipb.csic.es
Hagai Ginsburg
Department of
Biological Chemistry
Institute of Life
Sciences
The Hebrew
University of Jerusalem
Jerusalem 91904
Israel
hagai@vms.huji.ac.il
Ivan Hrdy
Charles University
in Prague,
Vinicna 7
CZ-128 44 PRAHA 2
Tel: +420/2219 51
812
Fax: +420/2249 19
703
hrdy@
natur.cuni.cz
Sanjeev Krishna
St Georges Hospital Medical School
Cranmer Terrace
London
SW17 0RE
sgjf100@sghms.ac.uk
Jaroslav Kulda
Charles University
in Prague,
Vinicna 7
CZ-128 44 PRAHA 2
Tel: +420/2219 51
812
Fax: +420/2249 19
703
kulda@natur.cuni.cz
Michael Lanzer
Abteilung Parasitologie
Hygiene Institut
Im Neuenheimer Feld 324
D-69120 Heidelberg
Germany
Tel.: (++49) 6221 567845
Fax:
(++49) 6221 564643
E-mail:
Michael.Lanzer@med.uni-heidelberg.de
Alexandra Luescher
University of Bern, Institute of Cell
Biology,
Baltzerstrasse 4,
CH-3012 Bern
alexandra.luescher@
izb.unibe.ch
Annette MacLeod
Wellcome Centre For Molecular
Parasitology
Anderson College
56 Dumbarton Road
Glasgow
G11 6NU
UK
gvwa08@udcf.gla.ac.uk
Pascal Mþser
University of Bern, Institute of Cell
Biology,
Baltzerstrasse 4,
CH-3012 Bern
pascal.maeser@izb.unibe.ch
Rita Mukhopadhyay
Department of Biochemistry and
Molecular Biology
Wayne State University School of Medicine
540 East Canfield Avenue, #5321
Detroit, MI 48201
Tel: (313)577-0618
FAX: (313)577-2765
rmukhopa@med.wayne.edu
Sylke MŸller
Infection & Immunity
Joseph Black Building
University of Glasgow
Glasgow G12 8QQ
UK
tel: ++ 44 141 330 2383
Lisa Ranford-Cartwright
Division of Infection & Immunity
Institute of Biomedical & Life Sciences
Joseph Black Building
University of Glasgow
Joseph Black Building, Glasgow G12 8QQ
Scotland,
UK
Tel: 00 44 141 330 2639
Fax: 00 44 141 330 4600
L.Ranford-Cartwright@bio.gla.ac.uk
Madhubala Rentala
School of Life Sciences
Jawaharlal Nehru University
New Delhi -110067
Andreas Rohwer
Akzo Nobel
Intervet Innovation GmbH
Drug Discovery / BioChemInformatics
Zur Propstei
55270 Schwabenheim / Germany
Phone +49 (0)6130-948-206
Fax +49 (0)6130-948-517
Mobile +49 (0)1735730576
Andreas.Rohwer@intervet.com
Marlene Roos
RoosProjectConsult,
Harderwijkerweg 170,
8077RK Hulshorst,
Nederland.
m.h.roos@planet.nl
Efi Scoulica
Department of Clinical Bacteriology,
Parasitology, Zoonoses and Geographical Medicine
School of Medicine
University of Crete
76309, Heraklion
Greece
scoulica@med.uoc.gr
Thomas Seebeck
University of Bern, Institute of Cell
Biology,
Baltzerstrasse 4,
CH-3012 Bern
thomas seebeck
[thomas.seebeck@izb.unibe.ch]
Dennis Sereno
IRD UR008 "Pathogenie des
Trypanosomatides"
Institut de Recherche pour le Developpement
Centre IRD de Montpellier
911 Av. Agropolis, BP 64501
34394 Montpellier Cedex 5
France.
Denis.Sereno@mpl.ird.fr
Ivor Tittawella
Dept of Molecular Biology
University of UmeŒ
901 87 UmeŒ
SWEDEN
Tel.: +46 (0)90 785 3977 (wk)
+46 (0)90 13 82 35 (res)
e.mail: ivor.tittawella@molbiol.umu.se
Patrick Trieu-Cuot
Department of Fundamental and Medical
Microbiology
Institut Pasteur
25,28 rue du Docteur Roux
75724 Paris CEDEX 15 - FRANCE
ptrieu@pasteur.fr
Nina Ulrich
Department of Inorganic Chemistry
University of Hannover
Germany.
Ulrich@mbox.acc.uni-hannover.de
Henri Vial
Dynamique moleculaire des Interactions Membranaires
CNRS UMR 5539
Universite Montpellier II, case 107
Place Eugene Bataillon
34095 Montpellier Cedex 05, France
Tel : +33 - (0) 4 6714 3745)
+33 - (0) 4 6714
42 87 (secretary)
Fax : +33 - (0) 4 6714 42 86
e-mail: vial@univ-montp2.fr
Steve Ward
Molecular & Biochemical Parasitology
Group
Liverpool School of Tropical Medicine
Liverpool L3 5QA
United Kingdom
saward@liverpool.ac.uk
Vanessa Yardley
Dept. of Infectious & Tropical Diseases
LSHTM
Keppel Street
London
WC1E 7HT
Tel:
00 +44 020 7927 2462 (office)
00 +44 020 7927 2053 (lab)
07890 173580 (mobile)
Fax: 00 +44 020 7927 2807
Vanessa.Yardley@lshtm.ac.uk
Dan Zilberstein
Faculty of Biology
Technion - Israel Institute of Technology
Haifa 32000, Israel
Tel: 972-4-8294211-2
Fax: 972-4-8295670
E-mail: danz@techunix.technion.ac.il