COST
Action B22 on "Drug development for parasitic diseases"
2003-2007
36th
Microsymposium 'Glycosomes and Drug Design'
COST B22 Expert Meeting 'Energy metabolism of parasitic protozoa as a drug target'
Thursday 7 and Friday 8 October, 2004
Michel de Visscher Auditorium
ICP,
Brussels
Participants
How
to get at the ICP
Programme
Thursday,
7 October 2004
09.00-09.30 Welcome
and coffee Morning
session chairman: Paul Michels 09.30-09.35 Paul
Michels (Brussels) Introductory remarks 09.35-10.05 Véronique
Hannaert, with Marie-Astrid Albert and Paul Michels
(Brussels) Glycolytic
enzymes as drug targets in bloodstream-form
Trypanosoma brucei; quantitative assessment by RNA
interference studies 10.05-10.25
Barbara
Bakker (Amsterdam) Differential
control analysis of glucose metabolism in erythrocytes
and trypanosomes 10.25-10.50 Jurgen
Haanstra (Amsterdam) Synergy
and antagonism of glycolysis inhibitors against
Trypanosoma brucei from model to
experiment 10.50-11.10
Tea/coffee
break 11.10-11.35
Daniel
Rigden (Liverpool) An
update on the mysteries of trypanosome fructose
2,6-bisphosphate metabolism 11.35-12.05 Michael
Ginger (Oxford) Providing
functional roles for the adenylate kinase and arginine
kinase gene families in trypanosomatids 12.05-12.30 Cédric
Yernaux, with Paul Michels (Brussels) The
putative fatty-acid carriers in the glycosomal membrane
of Trypanosoma brucei 12.30-14.00
Lunch
in University Restaurant 'Le Martin V' Afternoon
session chairman: Louis Tielens 14.00-14.30 Frank
Voncken (Heidelberg) Glycosomal
and mitochondrial metabolite carriers from Trypanosoma
brucei 14.30-15.00 Jaap
van Hellemond, with Louis Tielens (Utrecht) Does
the environment determine the mitochondrial metabolism in
Trypanosomatidae ? Clues from T.
theileri Michael
Boshart (Munich), with Louis Tielens (Utrecht) and
Frédéric Bringaud (Bordeaux) Acetate:succinate
CoA-transferase in Trypanosoma brucei 15.30-16.00 Tea/coffee
break 16.00-16.20 Frédéric
Bringaud, with V. Coustou, S. Besteiro and L. Riviere
(Bordeaux) Involvement
of a mitochondrial NADH-dependent fumarate reductase in
succinate excretion 16.20-16.50 Achim
Schnaufer (Seattle) RNA
editing and its role in energy metabolism throughout the
life cycle of trypanosomes 16.50-17.20 Julius
Lukes (Ceske Budejovice) Functional
analysis of accessory factors in RNA editing in
Trypanosoma brucei 17.20-
Drinks
in the ICP Dinner
in Brussels
Friday, 8 October 2004
09.00-09.30 Coffee Morning
session chairman: Malcolm Walkinshaw 09.30-09.55 Linda
Gilmore, with Iain McNae, Jose Martinez-Oyanedel &
Malcolm Walkinshaw (Edinburgh) Protein-ligand
interactions in Trypanosoma brucei PFK 09.55-10.15 Marcos
Navarro, with Matt Nowicki, Linda Gilmore & Malcolm
Walkinshaw (Edinburgh) Analogue-based
and protein-structure-based inhibitors of Trypanosoma
brucei PFK 10.15-10.35 Buabarn
Poonperm, with Linda Gilmore & Malcolm Walkinshaw
(Edinburgh) Leishmania
mexicana iPGAM: metals and inhibitors 10.35-10.55 Lindsay
Tulloch, with Linda Gilmore & Malcolm Walkinshaw
(Edinburgh) Inhibitors
of Leishmania mexicana PYK 10.55-11.25 Tea/coffee
break 11.25-11.55 Jurgen
Sygush (Montreal) Reaction
complexes in Leishmania mexicana aldolase and the
methylglyoxal synthase activity 11.55-12.25 Casimir
Blonski, with Sabine Gavalda (Toulouse) Inhibition
studies on Trypanosoma brucei enolase 12.25-14.00 Lunch
in University Restaurant 'Le Martin V' Afternoon
session chairman: Frédéric
Bringaud 14.00-14.30 Fred
Opperdoes (Brussels) Lessons
from the TriTryp genome comparative analysis 14.30-15.00 Antonio
Uttaro (Rosario) Metabolic
studies in Phytomonas 1500-15.25 Paul
Michels, with Hanane Krazy, Nathalie Galland (Brussels)
and Wim Hol (Seattle) Glycosome
biogenesis as drug target in trypanosomatids 15.25-15.55 Tea/coffee
break 15.55-16.10 Nathalie
Galland, with Juliette Moyersoen and Paul Michels
(Brussels) Glycosomal
matrix protein import analyzed by RNA
interference 16.10-16.30 Murielle
Herman, with Paul Michels (Brussels), David Perez-Morga
and Cécile Felu (Gosselies) Degradation
of glycosomes during the differentiation of
Trypanosoma brucei from the bloodstream to the
procyclic form 16.30 General
discussion Farewell
drinks/dinner